Define a query for joining data

Hey around,

I´m trying to build a query that provides access to features within a FC that intersect a given geometry AND that apply to an attribute-based query from another table by a join. For the last one I may use the IQueryDef-interface as it allows joining data based on an attribute-based query, but I need both - a spatial and a attribute-component. Is there any better way then creating one of the filters first, looping the results and checking every feature for the second condition? Maybe by building a temporary table using IQueryTable from the QueryDef-object and than perform a spatial query on it?

Thanks in advance :D